JWH-018

Description

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JWH-081 like all other research chemicals in the JWH group, is a synthetic cannabinoid with analgesic effects. Its full chemical name is 4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone with chemical formula as C25H25NO2 and molecular mass 371.47 g/mol.

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Unlike THC, which is an incomplete agonist at CB1 receptors, buy JWH-018 online, and numerous engineered cannabinoids, are complete agonists. THC has been shown to interfere with the neurotransmission of the GABA receptor in the cerebellum through a few pathways. JWH-018 can cause extreme discomfort, hot flashes and, in rare cases (largely in non-standard JWH clients), is expected to cause seizures and spasms by inhibiting GABA neurotransmission more adequately than THC. Full cannabinoid receptor agonists can pose real dangers to the client when used excessively.

Several physical and mentally unfriendly effects have been observed with the use of JWH-018 purchased online. One study described delusional relapses and uncomfortable side effects in all-around treated patients with mental illness after inhalation of JWH-018.[21] Due to concerns about the ability of JWH-018 and other manufactured cannabinoids to induce psychosis in frail individuals, it has been suggested that individuals with risk factors for manic disorders (such as a history or family background of psychosis) not use these substances.

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